The Gunners manager has urged his reinvigorated side to take full advantage of Tottenham's recent stuttering form and move seven points clear of their north London neighbours
Wenger's side, who are currently two points behind Spurs, have games against Norwich City (on Saturday), Everton (on Tuesday April 16) and Fulham (April 20) before Tottenham welcome Manchester City to White Hart Lane on April 21.
Until recently, Spurs looked to have all-but secured fourth place, but their patchy form of late has seen the race for the top four heat up once again.
"Because they [Tottenham] don't play we have a chance to build an advantage. But since four or five weeks ago we know we have to win our games whether they play or not," Wenger told the Daily Mail.
"We have to focus on our games. It does not matter whether Tottenham play or not. We have to win our games. This is a massive week for us.
"I'd rather have the points on the board. Tottenham will be hard competition until the end, Chelsea as well, and the only way we can deal with that is to look at ourselves and win our games."
Tottenham lost on penalties in the Europa League to Swiss outfit Basel in midweek, and Wenger added: "Is it an advantage for them being out of Europe? I don't know, you cannot speculate on that.
"Physically it's always an advantage, psychologically it's a disadvantage."