The London club's immediate programme includes two Premier League games, a Europa League fixture against Rubin Kazan and, on Monday, an FA Cup replay with Manchester United, all within nine days.
Benitez fumed to reporters: "Normally, if you have three days between games, you can see the players are tired. When it's two days, it's impossible.
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"You have to put things together rather than having just one priority because lots of things are an influence, including analysing the players and the scouts' reports.
"In terms of trying to prepare the tactics for the United game, that's fine, but physiologically it is much harder. You feel fine the day after a game but the second day is much harder and it will be really tough for everyone."
While United can afford to rest key players against Sunderland on Saturday with their 15-point lead at the top of the Premier League providing a mammoth protection barrier against any slips-up, Benitez understands that Chelsea do not have the depth to match that of Sir Alex Ferguson's side.
The Spaniard continued: "It is impossible to be fully fit for two games. All of them can play, but at which level?
"Sometimes you can win if you are not 100 per cent because you are just better than the other team but that depends on the position of the players who are tired and the opposition.
"Now we have to make these decisions. We know that if we win, it will be that we did the right thing. But if not, we'll be told, 'You made a mistake'."