Jamie Carragher is left out of the squad entirely and Lucas drops to the bench as Brendan Rogers makes two changes to his side for the trip to St Mary's
Liverpool, meanwhile, make two alterations from the side that beat Tottenham 3-2 last time out as Martin Skrtel takes Jamie Carragher's place at the heart of defence with Jamie Carragher left out of the squad.
There is also a return for Joe Allen, who comes in for Lucas in the centre of midfield, despite the fact that the Welshman may face shoulder surgery in the near future.
Southampton: Boruc; Clyne, Yoshida, Hooiveld, Shaw; Schneiderlin, Cork, Lallana, Ramirez; Rodriguez, Lambert.
Subs: K Davis, Fonte, S Davis, Forren, Ward-Prowse, Guly, Puncheon.
Liverpool: Jones; Johnson, Skrtel, Agger, Enrique; Downing, Gerrard, Allen, Coutinho; Suarez, Sturridge.
Subs: Gulacsi, Wisdom, Henderson, Shelvey, Lucas, Suso, Ibe.