Southampton make just one change from the side that drew 0-0 draw at Norwich City last weekend as Nathaniel Clyne returns at right-back to replace Jose Fonte who drops to the bench.
Liverpool, meanwhile, make two alterations from the side that beat Tottenham 3-2 last time out as Martin Skrtel takes Jamie Carragher's place at the heart of defence with Jamie Carragher left out of the squad.
There is also a return for Joe Allen, who comes in for Lucas in the centre of midfield, despite the fact that the Welshman may face shoulder surgery in the near future.
Southampton: Boruc; Clyne, Yoshida, Hooiveld, Shaw; Schneiderlin, Cork, Lallana, Ramirez; Rodriguez, Lambert.
Subs: K Davis, Fonte, S Davis, Forren, Ward-Prowse, Guly, Puncheon.
Liverpool: Jones; Johnson, Skrtel, Agger, Enrique; Downing, Gerrard, Allen, Coutinho; Suarez, Sturridge.
Subs: Gulacsi, Wisdom, Henderson, Shelvey, Lucas, Suso, Ibe.