John Terry and Fernando Torres are on the bench for the visiting Blues as Rafael Benitez prefers to pair Gary Cahill and David Luiz at the back and Demba Ba up front
Chicharito gets the nod up front and will be supported by Rooney, Nani and Shinji Kagawa. Michael Carrick and Tom Cleverley are paired in midfield.
Rafael Benitez, meanwhile, has left John Terry and Fernando Torres out of his starting XI, with Demba Ba starting in attack and David Luiz and Gary Cahill at centre-back.
Eden Hazard is on the bench so Victor Moses joins Juan Mata and Oscar behind Ba, with Frank Lampard and Ramires backing the attack up in central midfield.
Manchester United: De Gea; Rafael, Ferdinand, Evans, Evra; Nani, Carrick, Cleverley, Kagawa; Rooney, Hernandez.
Subs: Amos, Valencia, Anderson, Vidic, Young, Welbeck, Van Persie.
Chelsea: Cech; Azpilicueta, Luiz, Cahill, Cole; Ramires, Lampard; Mata, Oscar, Moses; Ba.
Subs: Turnbull, Ivanovic, Torres, Mikel, Hazard, Terry, Bertrand.