Sir Alex Ferguson has made wholesale changes to the team that faced Real Madrid, with Chicharito, Young and Valencia starting after being left out of the side on Wednesday
The Red Devils manager has decided to make major changes to the team that came away with a 1-1 draw against los Blancos, with only David de Gea, Phil Jones and Danny Welbeck keeping their place in the team, as Sir Alex looks to rotate his squad.
With the Old Trafford outfit fighting on all fronts for silverware, the veteran coach has fielded a strong team, with Chicharito given the nod up front.
The host look to return to a more traditional 4-4-2 formation, with wide men Ashley Young and Antonio Valencia lining up on the wings behind the young strike pairing.
Brian McDermott has also made several changes to the side that lost 2-1 to Stoke last weekend, with Sean Morrison, Jem Karacan, Nicky Shorey, Garath McCleary, Noel Hunt and Adam Le Fondre coming into the side.
Manchester United: De Gea; Jones, Smalling, Vidic, Buttner; Valencia, Cleverley, Anderson, Young; Welbeck, Chicharito.
Subs: Lindegaard, Ferdinand, Carrick, Giggs, Nani, Kagawa, Van Persie.
Reading: Federici; Kelly, Mariappa, Morrison, Shorey; McAnuff, Karacan, Leigertwood, McCleary; Hunt, Le Fondre.
Subs: Andersen, Gunter, Pearce, Carrico, Guthrie, Robson-Kanu, Pogrebnyak.