The full-back comes in for Laurent Koscielny who was injured in the warm-up, while Lee Cattermole returns from injury for the hosts as they look for a vital three points
The Frenchman had been set to start the game, but now misses out with Jenkinson coming into the team at full-back and Bacary Sagna moving into a central role alongside Per Mertesacker.
Olivier Giroud continues up front on his own, with a central midfield of Mikel Arteta, Santi Cazorla and Jack Wilshere, fresh from his England heroics against Brazil; Theo Walcott and Aaron Ramsey offer support out wide.
The hosts, meanwhile, start with Craig Gardner at right-back and on-loan Tottenham left-back Danny Rose, with a central pairing of Titus Bramble and John O'Shea.
Lee Cattermole makes his return from injury alongside new signing Alfred N'Diaye and Jack Colback in midfield, while Danny Graham has to settle for a place on the bench as top scorer Steven Fletcher is the lone frontman with support from Adam Johnson and Stephane Sessegnon.
Sunderland: Mignolet; Gardner, Bramble, O'Shea, Rose; Cattermole, N'Diaye, Colback; Johnson, Sessegnon, Fletcher.
Subs: Bardsley, Larsson, Graham, Vaughan, Mangane, Cuellar, Westwood.
Arsenal: Szczesny; Jenkinson, Mertesacker, Sagna, Monreal; Arteta, Wilshere; Walcott, Cazorla, Ramsey; Giroud.
Subs: Diaby, Rosicky, Podolski, Oxlade-Chamberlain, Miquel, Mannone.