The England international is handed a big chance to impress by Sir Alex Ferguson, while Brendan Rodgers' new signing Daniel Sturridge is forced to settle for a role on the bench
Shinji Kagawa starts for the hosts, with Rio Ferdinand and Nemanja Vidic forming the partnership in central defence.
New Liverpool signing Daniel Sturridge is on the bench for the visitors, with Luis Suarez supported on the flanks by Raheem Sterling and Stewart Downing.
Andre Wisdom starts at the back for the Reds, while Steven Gerrard, Joe Allen and Lucas form a midfield three for Brendan Rodgers' side.
Michael Carrick and Tom Cleverley are Sir Alex Ferguson's preferred choice in the middle, while Anderson returns from injury to take a role among the substitutes.
Manchester United starting XI: De Gea; Rafael, Ferdinand, Vidic, Evra; Cleverley, Carrick, Kagawa, Young; Welbeck, Van Persie.
Subs: Amos, Smalling, Jones, Valencia, Anderson, Giggs, Chicharito.
Liverpool starting XI: Reina; Wisdom, Johnson, Agger, Skrtel; Lucas, Gerrard, Allen; Downing, Sterling, Suarez.
Subs: Jones, Carragher, Henderson, Sturridge, Borini, Shelvey, Robinson.