The Potters manager says he will make changes for Saturday's match against Crystal Palace at Selhurst Park but insists the club will treat the competition with respect
The Potters lost 1-0 to Manchester City in the final of the competition in 2011 but were knocked out of the Capital One Cup earlier this season by Swindon Town after Pulis rested a number of key players.
Ahead of Saturday's clash with Crystal Palace, the Stoke boss says that although the league remains his main focus this season, they will treat English football's oldest club competition with respect.
"The Premier League is the main priority without a question of a doubt but we want to do well. We've proved that we do take the FA Cup seriously," he told reporters.
"I'll certainly change one or two because I think one or two need a rest but we'll show Palace the utmost respect because I've got respect for Ian [Holloway] and also Crystal Palace.
"It's a great football club. If they get back in the Premier League, they'll be filling that place week in, week out.
"We know how difficult it will be. Out of all the draws you could get, when it came out we looked at it and thought it was going to be a really difficult game, and it will be because they're flying in the Championship."
Palace currently sit third in the Championship table but have won only one of their last six matches.