The young midfielder has been handed a starting berth by Gunners boss Arsene Wenger for the first time in over a year following a lengthy battle with injury
The 20-year-old missed the entirety of the last campaign with an ankle injury and has suffered numerous setbacks which have delayed his return.
However, after coming through a recent reserves game against West Brom and making the bench for his side's loss to Norwich last time out, the Englishman has been handed a start by Arsene Wenger.
Wilshere is joined by Bacary Sagna, who is making his first start for the north London side since breaking his leg against Norwich last season.
Wenger has made three changes in all to the side which lost to Schalke last time out, with Francis Coquelin, Gervinho and Carl Jenkinson making way whilst Olivier Giroud returns to the attack.
QPR boss Mark Hughes has made just one change following his side's draw with Everton, as Shaun Wright-Phillips replaces Park Ji-Sung in midfield.
Arsenal starting XI: Mannone; Sagna, Vermaelen, Mertesacker, Santos; Arteta, Wilshere, Ramsey; Cazorla, Podolski, Giroud.
Subs: Martinez, Koscielny, Jenkinson, Coquelin, Walcott, Arshavin, Gervinho.
QPR starting XI: Cesar; Bosingwa, Nelsen, Mbia, Traore; Wright-Phillips, Diakite, Granero, Hoilett; Taarabt; Zamora.
Subs: Green, Ferdinand, Cisse, Onuoha, Mackie, Ephraim, Faurlin.