The hosts are without Tom Cleverley and Shinji Kagawa against the Potters but name an attacking line-up with Wayne Rooney, Danny Welbeck and Robin van Persie all included
David De Gea continues in goal as Sir Alex names the same defence that featured in the win at Newcastle last time out.
England trio Michael Carrick, Wayne Rooney and Danny Welbeck all feature, as does Robin van Persie, but there is no room in the squad for Tom Cleverley or Shinji Kagawa.
Stoke, meanwhile, make just one change from the side that drew 0-0 with Liverpool at Anfield with Dean Whitehead coming in from Glenn Whelan. Former United striker Michael Owen, starts on the bench.
Manchester United: De Gea; Rafael, Ferdinand, Evans, Evra; Scholes, Carrick; Valencia, Rooney, Welbeck; Van Persie
Subs: Lindegaard, Anderson, Giggs, Hernandez, Nani, Powell, Wootton
Stoke City: Begovic; Cameron, Shawcross, Huth, Wilson; Walters, Whitehead, Nzonzi, Adam, Kightly; Crouch.
Subs: Sorensen, Palacios, Jones, Owen, Upson, Etherington, Wilkinson