Jack Wilshere, Andre Santos and Emmanuel Frimpong are poised to start for Arsenal Under-21s against Reading on Monday night, Goal.com has learned.
The trio have been selected to begin the match for the club's second string team at Underhill.
Wilshere is set to make his second appearance in a week as he steps up his recovery from injury following 14 months on the sidelines.
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He is expected to be joined in central midfield by fellow 20-year-old Frimpong, who also returned last Monday following seven months out with a knee injury.
Sources have told Goal.com that Santos is also, more surprisingly, set to figure against Reading. The Brazilian was a second-half substitute for the Arsenal team that beat West Ham 3-1 last Saturday.
He will take one of the three over-aged places allowed in the Under-21 league.
Arsene Wenger is keen for Santos to have some game time after making only one start for the first team this season.
Kieran Gibbs, who has pulled out of the England squad with a minor thigh problem, has started every Premier League and Champions League match this season at left-back in place of Santos.