The England forward is one of many first-team players named by Sir Alex Ferguson for the Red Devils' cup tie at Old Trafford, where they face Alan Pardew's men
Sir Alex Ferguson also hands starts to Darren Fletcher, Tom Cleverley and Anderson in midfield, with David De Gea returning in goal.
The Red Devils' boss, however, names an unexperienced defence with Scott Wootton, Michael Keane and Marnick Vermijl lining up alongside summer signing Alexander Buttner.
Alan Pardew makes a number of changes from his first-team side that beat Norwich in the Premier League, with Rob Elliot starting in goal and Shola Ameobi also getting the nod up front.
Elsewhere Dan Gosling, Haris Vuckic and James Tavernier all play, alongside more recognised faces such as Fabricio Coloccini, Cheick Tiote and Gabriel Obertan.
Manchester United starting XI: De Gea; Vermijl, M Keane, Wootton, Buttner; Fletcher, Cleverley, Anderson; Rooney, Welbeck, Hernandez
Subs: Evans, Johnstone, Lingard, Tunnicliffe, Brady, Powell, King.
Newcastle United starting XI: Elliot; Perch, Williamson, Coloccini, Tavernier; Obertan, Tiote, Gosling, Marveaux; Vuckic; Shola Ameobi
Subs: Harper, Ferguson, Bigirimana, Anita, Amalfitano, Sammy Ameobi, Cisse