The 24-year-old has not featured since picking up a knee injury in City's opening Premier League clash with Southampton and had been called up for the Albiceleste's matches with Paraguay and Peru, to Roberto Mancini's displeasure.
|18/1||Argentina are 18/1 with PaddyPower to beat Peru 4-0|
Posting on the social networking website Twitter, Aguero confirmed he has not managed to shake off his knock in time to feature for his country.
He said: "It seems I won't be able to make it to the Peru match - but the effort was still worth it, I'll continue the recovery work at Manchester.
"Rooting for to the guys for the Peru match, I hope I can join them next time. Returning to @MCFC now to ready for the upcoming challenge."