Roberto Di Matteo clearly has one eye on Tuesday's semi-final second leg with Barcelona whilst Arsene Wenger makes four changes for the home side
Petr Cech, Gary Cahill and John Terry are the only three members of the midweek side to keep their place as the Italian manager looks to preserve his players for Tuesday's Champions League semi-final second leg against Barcelona.
Branislav Ivanovic completes his three-match suspension, whilst David Luiz and Didier Drogba are out with hamstring and knee problems respectively.
Ashley Cole, John Obi Mikel, Frank Lampard, Raul Meireles and Juan Mata all drop to the bench, whilst Ramires is rested.
Arsenal, meanwhile, make four changes to the side that lost to Wigan on Monday night.
Mikel Arteta was forced off after just eight minutes with ankle ligament damage and is replaced by Aaron Ramsey whilst the exciting Alex Oxlade-Chamberlain comes in for the ineligible Yossi Benayoun, as the Gunners face his parent club.
Laurent Koscielny returns from a two-match suspension to replace Johan Djourou and Kieran Gibbs comes in for Andre Santos in the other two changes.
Arsenal: Szczesny; Sagna, Koscielny, Vermaelen, Gibbs; Ramsey, Song, Rosicky; Walcott, Van Persie, Oxlade-Chamberlain.
Subs: Fabianski, Djourou, Santos, Diaby, Coquelin, Gervinho, Chamakh.
Chelsea: Cech; Bosingwa, Cahill, Terry, Bertrand; Essien, Romeu, Malouda; Sturridge, Torres, Kalou.
Subs: Turnbull, Ferreira, Cole, Lampard, Mikel, Mata, Meireles.