The Mexican is one of three changes from the side who beat QPR, with Phil Jones and Ryan Giggs coming into the fray, while Roberto Martinez picks an unchanged side
The Mexican is preferred to Danny Welbeck but, while the young England striker is on the Red Devils' bench, Paul Scholes and Rafael miss out altogether following United's win over QPR last time out.
Phil Jones and Ryan Giggs are the other men to come in having made substitute appearances in the 2-0 victory against Mark Hughes' men, while Antonio Valencia faces his former side.
Wigan, who begin the match in 19th place in the Premier League, have elected to field exactly the same XI who ran Chelsea close at Stamford Bridge despite losing 2-1.
Franco Di Santo leads the line for the Latics with Victor Moses and Shaun Maloney flanking him as Roberto Martinez, revealed by Goal.com today to be leaving his post at the end of the season, seeks to overturn the league leaders.
Wigan starting XI: Al Habsi; Boyce, Alcaraz, Caldwell, Figueroa, Beausejour; McCarthy, McArthur; Moses, Di Santo, Maloney
Subs: Crusat, Watson, Pollitt, Gomez, Sammon, Diame, Stam
Manchester United starting XI: De Gea; Jones, Evans, Ferdinand, Evra; Valencia, Carrick, Giggs, Young; Chicharito, Rooney
Subs: Smalling, Park, Nani, Welbeck, Cleverley, Amos, Pogba
More to follow ...