Club captain Ledley King and Jake Livermore also make the starting line-up, whilst Gareth Bale has shrugged off the knock he took late on at the Stadium of Light to also start.
William Gallas, Scott Parker, Sandro, Rafael van der Vaart and Emmanuel Adebayor are the players to make way.
Norwich City boss Paul Lambert makes three changes from the side that drew 2-2 at Carrow Road with Everton on Saturday, with Bradley Johnson, Anthony Pilkington and Aaron Wilbraham coming in.
Tottenham starting XI: (4-4-2): Friedel;Walker, Kaboul, King, Assou-Ekotto; Lennon, Livermore, Modric, Bale; Saha, Defoe.
Norwich Starting XI: (4-4-2): Ruddy; R.Bennett, Martin, Ward, Drury; E.Bennett, Johnson, Howson, Pilkington; Wilbraham, Holt.