Steven Gerrard starts alongside the expensively-assembled strike partnership for the first time as the Reds look at avoid upset against Newcastle's fourth-round conquerors
Kenny Dalglish makes three changes to the Liverpool side which lost to Manchester United in the Premier League last weekend.
Carroll returns to the starting line up to partner Suarez up-front, Jamie Carragher replaces Daniel Agger alongside Martin Skrtel in defence, whilst Charlie Adam comes in for Jay Spearing.
Meanwhile, Brighton start with struggling striker Craig Mackail-Smith on the bench and are forced to leave out cup-tied pair Gonzalo Jara and Joe Mattock.
Liverpool: Reina; Johnson, Carragher, Skrtel, Enrique; Henderson, Gerrard, Adam, Downing; Suarez, Carroll.
Subs: Doni, Maxi, Coates, Kelly, Kuyt, Shelvey, Spearing.
Brighton: Brezovan; Calderon, Greer, Dunk, El Abd; Buckley, Navarri, Bridcutt, Lua Lua; Barnes, Vokes.
Subs: Ankergren, Noone, Mackail-Smith, Rodriguez, Harley, Vincelot, Agdestein.