The young Englishman makes his first Premier League start for the Gunners as defender Thomas Vermaelen returns from injury and both sides lose experienced stars
The Gunners winger made his debut as a substitute in this season's reverse fixture at Old Trafford and joins the starting lineup alongside the returning Thomas Vermaelen.
Mikel Arteta and Thierry Henry are ruled out having failed to shake off recent knocks and Tomas Rosicky is the only other change for the Gunners from the side who were defeated at Swansea in their last outing.
Rio Ferdinand suffered a back injury in training and misses out for the visitors whilst Phil Jones and Chris Smalling return to the starting line up after missing last weekend's Premier League victory against Bolton.
Sir Alex Ferguson brings Ryan Giggs back into Manchester United's midfield replacing Paul Scholes who scored his side's opener last week.
Arsenal: Szczesny; Djourou, Mertesacker, Koscielny, Vermaelen; Ramsey, Song, Rosicky; Walcott, Van Persie, Oxlade-Chamberlain.
Subs: Almunia, Park, Squillaci, Arshavin, Benayoun, Miquel, Yennaris.
Manchester United: Lindegaard; Smalling, Jones, Evans, Evra; Valencia, Carrick, Giggs, Nani; Welbeck, Rooney.
Subs: De Gea, Fabio, Rafael, Scholes, Park, Berbatov, Hernandez.