United inflicted Arsenal’s worst defeat for over 100 years with a thumping 8-2 victory at Old Trafford.
Having lost their last two games, Djourou believes his team must use the pain of the defeat to spur them on against Sir Alex Ferguson’s side on Sunday.
"It's a fantastic game for us after Swansea which was difficult to swallow," the Switzerland international told The Sun.
"It will be a bounce-back game. We have to turn up, we have the away game still in our minds so there is revenge to take.
"We have to keep working hard to try to improve."
Having qualified for the Champions League for the past 14 consecutive seasons, Arsenal currently sit four points off the top four and are in danger of failing to qualify for Europe’s premier club competition.
However, Djourou is remaining positive about the task in hand, and says a top-four finish is well within their grasp.
"We have to fight to get in the top four," he added.
"It will be a difficult task but there is a long way to go."