Steven Gerrard misses out completely for the Reds while Potters boss Tony Pulis has made five changes from the side that lost 3-1 to Arsenal at the Emirates
Steven Gerrard is not included in the squad while Lucas Leiva does return to the starting XI to partner Jay Spearing in central midfield.
Uruguayan centre-back Sebastian Coates starts only his second game for the Reds having previously featured in the last round of the League Cup away at Brighton - a game which Liverpool won 2-1.
For Tony Pulis' side, Kenwyne Jones replaces Peter Crouch in attack while 22-year-old Ryan Shotton is given the nod and Jonathan Woodgate returns in defence.
Liverpool starting XI: Reina; Kelly, Coates, Carragher, Agger; Lucas, Spearing, Henderson; Maxi, Carroll, Suarez.
Subs: Doni, Aurelio, Kuyt, Adam, Bellamy, Skrtel, Flanagan.
Stoke City starting XI: Sorensen; Huth, Shawcross, Woodgate, Wilson; Shotton, Whelan, Delap, Etherington; Walters, Jones.
Subs: Nash, Diao, Pennant, Upson, Crouch, Jerome, Palacios.