The Gunners have already lost club captain Cesc Fabregas this week to Spanish giants Barcelona and are seemingly close to losing the French midfielder to Premier League rivals City.
However, Wenger believes that the playmaker will be committed to the cause if he plays against Kenny Dalglish’s side on Saturday.
“The only thing I can say is Nasri’s in the squad tomorrow and available to be picked and to play,” Wenger told reporters.
Asked if he had any doubts about playing him, Wenger responded: “Not at all. Because one thing I don’t question is the commitment of Samir Nasri to this club.
“Every day since he has arrived here and every day in pre-season, he had worked with a fantastic spirit in training.”
Meanwhile, Wenger has hit back at allegations that he breached Uefa rules during the midweek Champions League qualifier win over Udinese. The Frenchman watched the game from the stands as he was serving a touchline ban, with some saying that he had broken Uefa rules by communicating with his staff on the bench.
Asked whether the accusations have come as a shock, Wenger said: “Yes, a big surprise, but we are completely open to any enquiry from Uefa. We have nothing to hide, but I don’t think we have done anything wrong.
“I did not communicate with the bench. I did watch the game from the director’s box, that was quite enjoyable.
“So overall, if they want to make an enquiry we have nothing against that.”
Asked if the club had asked about the rules pre-match, Wenger replied: “Yes, that’s why I’m quite surprised that they need an enquiry, because they gave us the rules and we observed strictly what they told us.
“I don’t know why after the game, but during the game the rules changed. We did what they told us before – I didn’t go to the dressing room.
“It looks quite strange because you can only do the part of the rules that’s interesting for them.
“Fifteen [minutes] after the games you can talk to the media. If you cannot go to your dressing room then you cannot go through to the media.”
Questioned if the team will be appealing the charge, he added: “Of course we will.”
He added: “That’s part of the rules at the moment. I don’t have a problem with it, frankly.
“I can deal with that. I try to focus on making the right decisions for the club. And for the rest you have to get people to analyse your decisions. If they like that you have to accept it.”
Wenger has come under fire in recent weeks, with some suggesting that he has not invested well in the squad, but the Frenchman feels his new players will soon show their quality.
“If you look at the players we have brought in, you will notice very soon that we have brought top quality players in," he said.
“We’ve bought [Carl] Jenkinson, Gervinho, we have [Ryo] Miyaichi, we have [Alex Oxlade-] Chamberlain. You will soon see that they all are top quality players.
“And we have not lost so many players. We have lost, of course, big players, but number-wise we should be capable to do well.
“But if we find quality, we [will] add quality to our squad. We have worked very hard on it I must tell you and we have ever had the reputation as we have looking too much at the money that we want.
“To add top quality to our squad is all we want to do.”
He also added that he was "a bit short" in defence and midfield, and may make further reinforcements in these departments.