Kenny Dalglish hands competitive debuts to four of his summer signings while Wes Brown features at centre-back for the Black Cats with Connor Wickham on the bench at Anfield
Kenny Dalglish has also handed competitive debuts to summer signings Charlie Adam, Jose Enrique and Stewart Downing while Andy Carroll starts up front for the Reds at Anfield.
Young full-back John Flanagan, who impressed in the latter half of the season for the Merseysiders in 2009-10, starts at right-back with Jamie Carragher and Daniel Agger at the heart of the defence.
For Sunderland, new arrivals Wes Brown and Seb Larsson start while youngster Jack Colback is given the nod in midfield.
Summer signing from Ipswich Town Connor Wickham only makes the bench, along with fellow new-boys Craig Gardner, David Vaughan and Ji Dong-Won.
Liverpool starting XI: Reina; Flanagan, Carragher, Agger, Enrique; Henderson, Lucas, Adam, Downing; Suarez; Carroll.
Subs: Meireles, Kuyt, Spearing, Ngog, Doni, Kelly, Robinson.
Sunderland starting XI: Mignolet; Bardsley, Brown, Ferdinand, Richardson; Larsson, Elmohamady, Cattermole, Colback; Sessegnon; Gyan.
Subs: Gardner, Wickham, Vaughan, Dong-Won, Bramble, Westwood, Laing.