The newly crowned PFA Young Player of the Year starts among the subtitutes for Arsene Wenger's side, as Aaron Lennon makes way for Peter Crouch
On the back of his side's 1-1 draw at home to Liverpool at the weekend, Arsene Wenger has elected to pair Alex Song and Abou Diaby in central midfield, leaving Wilshere, who won the PFA Young Player of the Year on Sunday, on the bench.
Other than their change in midfield, Arsenal field the same side which were held to a point at the Emirates by Kenny Dalglish's men.
For Tottenham, their only change from the team which lost 1-0 at White Hart Lane in their Champions League second-leg tie with Real Madrid last Wednesday is in attack, as Harry Redknapp has reverted back to a 4-4-2, with Peter Crouch returning to partner Roman Pavlyuchenko. Aaron Lennon drops to the bench to allow Rafael van der Vaart to operate on the right.
Tottenham: Gomes; Corluka, Dawson, Gallas, Assou-Ekotto; Van der Vaart, Huddlestone, Modric, Bale; Crouch, Pavlyuchenko. Subs: Cudicini, Bassong, Kaboul, Lennon, Pienaar, Sandro, Defoe.
Arsenal: Szcezeny, Sagna, Djourou, Koscielny, Clichy, Diaby, Song, Fabregas, Nasri, Walcott, Van Persie. Subs: Lehmann, Squillaci, Gibbs, Ramsey, Wilshere, Arshavin, Bendtner.