A memorable night in Moscow ended in misery for the London side after the game went to penalties following a 1-1 finish, and what was then Avram Grant's side failed to overcome United in the shootout.
However, Chelsea have only recently beaten Sir Alex Ferguson's side and with the first leg being played at Stamford Bridge, where United have failed to win since 2002, confidence is high – but Cech believes it is still too close to call.
"If you want to win the Champions League you have to beat anybody, so at any stage it was clear we were going to play one of the English teams," he told the club's official website.
"I said before the draw I don't really look about possibilities of who I want to avoid or get - we know them, they know us, and we know what to expect.
"We know Old Trafford quite well, we've beaten them a few times, and they've beaten us a few times so we can both treat it as an advantage."
Meanwhile, Chelsea's focus for the time being is on the Premier League clash against Manchester City and Carlo Ancelotti's team will be hoping for all three points as they try to keep up with the leaders and secure themselves a place in next year's Champions League.
The champions can leapfrog Roberto Mancini's team with a win.
"This is a six-pointer," he added. "If we win we can go into third spot with a game in hand which will be a big help.
"And as well, if we want to hope for the chance of winning the title then we need to keep winning to keep the pressure on."