Brown watched helplessly as his side conceded an 84th minute goal to the home side when Ben Watson's delightful lob over Matt Duke, in the Hull goal, proved to be the match winner.
After the game, Brown was understandably downbeat about the result.
Speaking to BBC Sport, Brown said, "You can say it is cruel but our inexperience is something we have to learn from."
The Tigers boss also felt his side lacked belief in the first half, but slowly started to get into the game in the second half.
"There was a point, or three, to be had," added the 49-year-old. "First half we were disappointing, in terms of the way we played.
"Second half, slowly but surely, we were coming into it. I'm disappointed with the manner in which we lost it."
The result puts Wigan into 7th place in the Premier League table, chasing a European spot. It leaves Hull slowly sliding towards the relegation zone in 13th place, just four points above the bottom three.
Nick Turner, Goal.com