Jose Mourinho's reward for seeing off Stoke is a trip to face Manuel Pellegrini's free-scoring side and Brendan Rodgers' men will travel to Arsene Wenger's Premier League leaders
The draw threw up two more all top-flight affairs as Southampton travel to Sunderland and Everton set to entertain Swansea, which will give the lower flight teams left in the cup a boost with the prospect of a clutch of top teams being knocked out.
Brighton & Hove Albion will welcome Premier League side Hull to the south coast, while Ole Gunnar Solskjaer will have to navigate a tricky tie against holders Wigan if his Cardiff side are to progress.
Sheffield Wednesday and Charlton escaped a difficult tie against Premier League opposition as they face each other in an all-Championship clash, while the winners of the replays featuring Sheffield United and Fulham will take on the victors of Nottingham Forest's replay with Preston.
FA CUP FITH ROUND DRAW IN FULL:
Manchester City v Chelsea
Arsenal v Liverpool
Sheffield United/Fulham v Nottingham Forest/Preston
Brighton v Hull
Cardiff v Wigan
Sheffield Wednesday v Charlton
Sunderland v Southampton
Everton v Swansea