Blatter and Platini's appeals against infringements of general rules of conduct, loyalty, conflicts of interests and offering and accepting gifts and other benefits were rejected.
The appeal committee decided, however, that "strong mitigating factors" - such as the pair's service to Fifa and Uefa - were not taken into account when the original sanction was handed down.
Appeals from the investigatory chamber for life bans from all football-related activity to be imposed were turned away as breaches of the Fifa regulations on bribery and corruption could not be established.
Both Blatter and Platini will therefore be banned from all football-related activity for a period of six years backdated to October 15, 2015, when the original sanctions were imposed.
Platini will also be fined 80,000 Swiss francs (£58,000), while Blatter has been ordered to pay 50,000 Swiss francs (£36,000).