The Spain international is given the nod against his former club and will feature alongside emerging Belgian Romelu Lukaku for the visit of Kenny Dalglish's men
The Spaniard starts in attack against his former club alongside Romelu Lukaku, as Villas-Boas makes a number of changes to the side that defeated Wolves 3-0 on Saturday.
Ross Turnbull is given a rare start in goal, while young left-back Ryan Bertrand starts in place of Ashley Cole.
Highly-rated midfielder Josh McEachran features in a three-man midfield alongside the recalled Frank Lampard and former Barcelona youngster Oriel Romeu.
Liverpool boss Kenny Dalglish has made a number of adjustments to his starting XI from the 1-1 draw with Manchester City at the weekend, handing starts to defensive trio Jamie Carragher, Sebastian Coates and Martin Kelly.
Young midfielder Jay Spearing has been given a chance to impress in the heart of the Reds' midfield. At the head of attack, Craig Bellamy and Andy Carroll have both been recalled to the starting line-up after missing out against Roberto Mancini’s side.
Chelsea: Turnbull; Bosingwa, Alex, Luiz, Bertrand; McEachran, Romeu, Lampard; Malouda, Lukaku, Torres.
Subs: Hilario, Ferrira, Ivanovic, Ramires, Kalou, Mata, Anelka.
Liverpool: Reina; Kelly, Carragher, Coates, Enrique; Henderson, Spearing, Lucas, Maxi; Bellamy, Carroll.
Subs: Doni, Skrtel, Flanagan, Adam, Downing, Kuyt, Suarez.