The Blancos languish 12 points behind the Liga pace-setters with 10 games to play, with Zinedine Zidane admitting his side are unlikely to triumph domestically.
And the Barcelona coach did not miss the opportunity to point out he was more concerned with Diego Simeone's charges, who lie eight points back.
"Our closest rivals are Atletico, who are second; then Madrid, who are third," he told reporters in Friday's press conference.
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"We have a lead that we have earned, but we still have a lot of work to do."
Luis Enrique also defended tennis star Rafael Nadal, who was accused of doping by an ex-French minister.
"I have more chance of doping than Rafael Nadal. For me he is a model sportsman," he affirmed.
"I have complete trust in him. It seems they are going to make a complaint about the person who said it, and I think that's correct.
"He only has one defect - the team he supports!"