The Argentine forward came off the bench in the Clasico to make his first appearance since getting injured in September, and enjoyed a jubilant comeback as Barca romped to a 4-0 victory at the Santiago Bernabeu.
Ahead of Tuesday's Champions League tie with Roma at Camp Nou, Luis Enrique erased any doubts that Messi would be held back due to not being fully fit.
"He is back fit and this is a joy for us - to see the greatest player back again and now we get to enjoy him," he told reporters.
"Messi is fully recovered, he is already in the right frame of mind and his injury is forgotten. He has to recover his muscle tone and his form, but you have to play to recover that."
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The Spanish coach was also quick to dismiss the notion that there was friction between himself and his star player during the early days of his reign, though did hint that there are other players he gets on better with.
"I've always got on well with Messi," explained Luis Enrique when questioned over problems with Messi when he first arrived at Barcelona.
"I've always had good relationships with most of my players. I empathize more with some than others, but that is normal, like in school with classmates, but my relationship with all my players is good. What happens in the locker room stays there."