The forward is set to win his 100th Argentina cap against Jamaica and he is desperate to land major silverware with his country
The Barcelona phenomenon has won a plethora of honours at Camp Nou, triumphing in La Liga seven times, the Copa del Rey on three occasions and the Champions League four times.
However, success with Argentina has remained agonisingly out of reach for the four-time Ballon d'Or winner - he was part of the team that lost the 2007 Copa America final to Brazil and captained his nation as they lost to Germany in last year's World Cup final.
Gerardo Martino's men are on the cusp of a place in the quarter-finals in this year's Copa in Chile and, as he prepares to reach his century of appearances, Messi has vowed to do everything he can to lead the side to pick up the trophy at the end of the campaign.
"I would give everything win the Copa America," he told La Nacion. "This group deserves it for the way they fight. We had a great World Cup and we deserve it.
"It's what I dream of. Winning the Copa America would us some give peace of mind for the coming World Cup qualifiers. Not only for my team-mates, for the coach and for me, but for the country, too. The fans also want us to succeed."
Regarding his 100th cap - which will come in Saturday's Group B contest against Jamaica barring a late injury - Messi hopes that he will finally have some silverware to go with his century of international appearances.
"I'm very happy to be here and hopefully I can celebrate another victory and once and for all win a title with Argentina," he added.
"In these 100 games I have had incredible experiences, really great times. They are unforgettable.
"I've been through situations that have helped me grow as a player, but unfortunately with no title to show for it. Hopefully I'll have one to go with these 100 games."