The Manchester City forward made little impact during the Albiceleste's 2-1 win over Chile and could now be replaced by Higuain, while Demichelis enters for suspended Otamendi
Sergio Aguero is set to lose his place in Argentina's starting line-up for the next World Cup qualifier, according to La Nacion.
The Manchester City forward endured a frustrating spell on the pitch in Thursday's 2-1 win over Chile, as he spurned a few decent opportunities before being replaced in the second half.
And having received the nod over Gonzalo Higuain in Santiago, coach Gerardo Martino is leaning towards the Napoli man for the second of March's qualifying double-header in Cordoba.
There is better news for Martin Demichelis, who will start instead of suspended team-mate Nicolas Otamendi alongside Rosario Central defender Javier Pinola.
Probable Argentina XI: Romero; Mercado, Demichelis, Pinola, Rojo; Mascherano, Biglia, Banega; Messi, Higuain, Di Maria.