The Madrid man is relishing the prospect of teaming up with the 2011 Fifa Ballon d'Or winner once again in the World Cup 2014 qualifier against Uruguay
Higuain has nothing but praise for his compatriot, and believes it is nearly impossible for a defender to anticipate what the Barca man will do with the ball at his feet.
"I'm a forward and I have the chance to play with Messi. It's a privilege to play alongside him," Higuain told reporters.
"Every time he gets the ball you need to be on your toes because you know that at any moment he can give you a great ball or pull your marker away from you.
"He does things that a striker can anticipate but a defender can't. I know how Messi, [Angel] Di Maria and [Sergio] Aguero like to play."