The pair have been in the international wilderness for the past few years, but could feature against Venezuela after being included in the first team for Wednesday's practice
The pair are two of a host of changes made from the last time the Albiceleste took the field, in their ill-fated Copa America quarter-final against Uruguay. Demichelis has not appeared for Argentina since 2010's 1-0 victory over Ireland, while Lucho last took the field in 2009 when he scored in the humiliating 6-1 reverse against Bolivia.
Ole reports that new Inter arrival Ricky Alvarez also appeared in the first-team during Wednesday's training session, as did Porto's Nicolas Otamendi, while Lionel Messi lined up on the right side of a three-man attack alongside Real Madrid's Gonzalo Higuain and Angel Di Maria.
Sabella is yet to confirm his final line-up for the friendly, which will kick off at 15:30 CET.
Possible Argentina XI:
Romero; Zabaleta, Demichelis, Otamendi, Rojo; Lucho González, Mascherano, Ricky Alvarez; Messi, Higuain and Di María