The former Roma boss believes it's the perfect time to take charge of the San Siro side and would be happy to work with Mario Balotelli
The San Siro side are in the market for a new trainer, with current boss Massimiliano Allegri set to leave at the end of the 2013-14 campaign, and Spalletti would relish the chance to return to Serie A after previous spells with Roma and Udinese.
"From a coach's point of view, this is the perfect time to take charge of Milan," Spalletti was quoted as saying by La Gazzetta dello Sport.
"Everybody knows that a number of things will have to change at the Rossoneri. One cycle has come to an end and it's now time to start a new cycle.
"I have a contract with Zenit until June 2015, but things can change quickly in football. You have to be ready to change course."
The 54-year-old then went on to discuss Milan striker Mario Balotelli and stressed that he would have plenty of advice for the Italy international.
"Why would I not want to work with Balotelli... I would have a few words of advice for him.
"Balotelli is a strong player with a lot of quality, but he needs the right guidance. It's a matter of time until the next strange incident, that's for sure."