La Roja's coach has acknowledged he faces a tough decision to pick between three top glovemen
Iker Casillas would normally be one of the first names on la Roja's team sheet and indeed started in the friendlies against the Republic of Ireland and Haiti.
But after losing his place in the Real Madrid side to Diego Lopez, Victor Valdes and Pepe Reina could get the nod ahead of the 32-year-old.
"On Sunday we will know what the lineup is," the 62-year-old Spaniard was quoted by Marca.
"Roughly I have decided but the three goalkeepers are excellent, which they have shown at their clubs. Casillas has had a break but I do not think there would be any harm in playing him from tomorrow. We will seek the best solution.
"I understand Casillas because he is a guy with a lot of responsibility. It has not been easy for him."
Spain will hope to surpass their 2011 Confederations Cup efforts, after suffering a semi-final exit at the hands of the United States two years ago.
And ahead of the fixture, Del Bosque was keen to stress the quality of their Group B opponents, who qualified for the tournament as a result of their 2011 Copa America triumph.
"We are not thinking of the semi-finals or final," the former Real Madrid boss declared.
"We're thinking of Uruguay, which is a very difficult game. They play good football and always want the ball. They also have a great coach [Oscar Tabarez], a gentleman.
"Uruguay also have 90% of their players playing abroad. This mixture of styles is ideal."