With the English side coming out on top at the end of last month in the reverse fixture, a win tonight would see City in pole position to join Bayern Munich in the next round of the competition.
After losing their first meeting with the Bavarians, Pellegrini knows his side must take their other opportunities if they are to qualify. Three points currently separate City and CSKA, with Bayern topping Group D with a perfect nine points.
Manchester City come into this match with only one defeat in six matches. After a late defensive error, Chelsea beat them with a last minute goal just over a week ago.
Apart from that result, Manuel Pellegrini's side have looked in good form, beating the likes of West Ham United and Newcastle away, as well as Everton and Norwich convincingly at home.
bet365 only see one result this evening, pricing the hosts at 1/5 (1.20) to take all three points.
When CSKA played City back in October, the Russians were on a shocking run of form, winning only once in seven matches and being beaten in five of those games.
However, since that defeat to Pellegrini's side, Leonid Slutsky's men have won their last three matches in all competitions.
Slutsky will hope that might inspire some confidence in his side who are true underdogs in this match. bet365 price them at 16/1 (17.00) to cause a major upset. The same firm price the draw at 13/2 (7.50).
With City currently scoring for fun, it's worth looking at the total team goals in the fixture to find a bet that stands out.
The hosts are 5/6 (1.83) with bet365 to score over 2.5 goals in the match. This seems like a fantastic price when you consider City have netted an astonishing 33 goals in their last 11 fixtures, which averages out at three goals scored per game.
It's not just the home side that look capable of netting the required goals though, CSKA have been struggling to keep the ball out of their own net in recent weeks, conceding 19 in their last 11. The statistics combined with Manchester City's irresistible attacking form of late mean it's certainly worth investing in this bet.
|Manchester City to score over 2.5 goals for a 2pt stake at 5/6 (1.83) with bet365
Sign up with bet365 for up to £200 in free bets