The Bayern Munich star has a minor thigh injury, while Rafael van der Vaart and Michel Vorm will miss the game in Paris due to illness
The Bayern Munich attacker suffered the injury during Saturday's 5-1 Bundesliga win over Schalke, in which the winger scored a hat-trick, and has consequently opted against taking any chances with his fitness by playing in Paris.
"Schalke got a bit frustrated toward the end of the game," Robben told De Telegraaf. "It does not look good, so I think it's better not to take any risks."
Meanwhile, Hamburg midfielder Rafael van der Vaart and Swansea goalkeeper Michel Vorm have also pulled out of the Oranje squad for Wednesday's match because of illness. Augsburg right-back Paul Verhaegh had previously already withdrawn due to a flesh wound.
Netherlands boss Louis van Gaal has only decided to call up Siem de Jong (Ajax) to replace the aforementioned players.