Wales boss Chris Coleman has accused Real Madrid of mishandling Gareth Bale's thigh injury, resulting in his withdrawal from the squad to face Macedonia and Belgium.
The 24-year-old attacker has played just three times for the Liga giants since completing a world-record £86 million move from Tottenham in August.
Coleman said: "I'm not surprised because we said all along it’s been tough for Bale, as he has done no pre-season and then he's thrown into the deep end.
"I would never criticise another manager - Carlo Ancelotti is a brilliant manager - but la Liga football is a different tempo to the Premier League.
"I can understand the thinking that the Premier League is the fastest, most dynamic. It is, so maybe Carlo was thinking Gareth could handle it. He’s a super athlete. But I did say in our last camp that he was nowhere near fit."
Coleman understands Bale's desire to play so soon after his big-money move, but has warned the player not to over-exert himself in the search for headlines.
He continued: "You have to put things in perspective. What has happened to him with the move, he must feel under pressure.
"He is probably trying too hard to do things that come naturally to him. Physically he is not there, he is not ready and he might not be for some time.
"If you don’t do a pre-season, no matter how good you are, you always play catch up for the season. This season might be a tough one for him, as good as he is.
"He has had the weight and stress of “will the move happen, won’t it?”. I think he has gone into it when he is not at his best, physically or mentally. It has had an effect.
"I hope I am wrong but I don’t think it will be the last one [injury] he gets this season because of the stress of everything. Physically he is not there yet. You can’t miss a pre-season."