England boss Roy Hodgson is without Kyle Walker (fibula), Tom Cleverly (calf), Steven Gerrard (shoulder), Andy Carroll (heel) and Jack Wilshere (ankle), who all pulled out of the squad through injury.
Gary Cahill has been playing alongside Phil Jagielka in training and that pair are expected to start in defence for the first England match since Rio Ferdinand joined John Terry in announcing his international retirement.
Daniel Sturridge is expected to start alongside Wayne Rooney in attack after finishing the season in fine form for Liverpool, while Ashley Cole will skipper the side.
Republic of Ireland boss Giovanni Trapattoni has opted not to risk Marc Wilson (calf), as the Stoke defender is struggling through injury, meaning Reading full-back Stephen Kelly comes into the side.
Sean St Ledger will partner John O'Shea in the centre of defense, with Aston Villa's Ciaran Clark left out of the squad through injury and Richard Dunne lacking match fitness.
Robbie Keane gained special dispensation from his club LA Galaxy to play in this friendly and he will be partnered up front by Shane Long, with Kevin Doyle (Achilles tendon) absent through injury.reland's first visit to England since 1991, with the game organised as part of the FA's ongoing 150th anniversary celebrations.The match had to be abandoned the last time these two nations met in 1995, as a minority of England fans provoked a riot at Dublin's Lansdowne Road that led to 20 arrests and 40 injuries. Ashley Cole (pictured, right) will captain the Three Lions after earning his 100th international cap against Brazil in February, though declined to perform other captain's duties such as speaking to the press.England have not beaten Ireland in any of their last five encounters, with the Boys in Green collecting five points from their last three qualifiers in London.The Three Lions are unbeaten in their last five games at Wembley, including victories over Belgium, Italy and Brazil.There are seven English-born players in Giovanni Trapattoni's squad.