The Italy coach believes he is the only person who can effectively handle the enigmatic striker because of the way he treats him as a person.
“I often say to Balotelli, jokingly, that maybe I'm the only one capable of managing him,” Prandelli told reporters.
“Perhaps it is because I have such little time for him.”
The Azzurri boss also heavily hinted that Paris Saint-Germain midfielder Marco Verratti and AC Milan striker Stephan El Shaarawy will feature in the friendly against France.
He added: “If we don't try these kids now, then when will we do it?”
Italy host Didier Deschamps’ side at Ennio Tardini stadium on Wednesday.