Mano Menezes has given recent Paris Saint-Germain acquisition Lucas Moura a starting berth for Brazil at the expense of Hulk while his soon-to-be club team-mate, Thiago Silva, figures among the substitutes against South Africa.
In their first game on home soil in over a year, the Selecao have made a few changes from the team that beat Sweden 3-0 in their last fixture. Lucas will start from the right side of attack as some impressive displays for Sao Paulo in the Brasileiro have earned him a spot of Zenit St Petersburg forward Hulk.
Brazil will have some more experienced hands in goal with the in-form stopper Diego Alves between the sticks but Thiago Silva will not be playing in front of him. Instead, Menezes has selected David Luiz and the highly-rated Dede to form his central-defensive duo.
Gordon Igesund has named an attacking side in his first game as South Africa coach but Benni McCarthy does not figure in the starting XI, with Thulani Serero, Lerato Chabangu and Dino Ndlovu forming the forward line. Dean Furman will be awarded his first international cap while late addition Sibosino Gaxa starts at right-back following the withdrawal of Anele Ngcongca through injury.
Brazil (4-2-3-1): Diego Alves; Dani Alves, Dede, David Luiz, Marcelo; Romulo, Ramires; Lucas, Oscar, Neymar; Leandro Damiao.
South Africa (4-3-3): Khune; Gaxa, Khumalo, Sangweni, Masenamela; Furman, Dikagcoi, Tshabalala; Serero, Chabangu, Ndlovu.