Coach Oscar Tabarez keeps faith with his party of 21 players to take on the Azzurri in Tuesday's friendly, after crushing Chile 4-0 in a World Cup qualifier on Friday
The 24-year-old scored all of his country's goals in a 4-0 rout of Chile in their World Cup qualifier on Friday, and the 2011 Copa America winners will hope to bring that destructive form to the Stadio Olimpico.
Coach Oscar Tabarez also has Napoli striker Edinson Cavani at his disposal and may look to continue in midfield with the Bologna duo of Diego Perez and Gaston Ramirez, who tore apart Chile.
Suarez, named player of the tournament in the summer's continental triumph, has a tremendous goalscoring record in internationals, having netted 26 times in 52 appearances for La Celeste.
Diego Forlan continues to miss out through injury as the South American outfit prepare to take on an Italy side who beat Poland 2-0 in a friendly on Friday.
Goalkeepers: Muslera (Galatasaray), Silva (Olimpia)
Defenders: Caceres (Sevilla), Scotti (Colo Colo), Lugano (Paris Saint-Germain), Godin (Atletico Madrid), Coates (Liverpool)
Midfielders: Arevalo Rios (Tijuana), Eguren (Sporting Gijon), Perez (Bologna), Gonzalez (Lazio), Alvaro Pereira (Porto), Maximiliano Pereira (Benfica), Cristian Rodriguez (Porto), Diego Rodriguez (Defensor), Ramirez (Bologna), Lodeiro (Ajax)
Forwards: Cavani (Napoli), Suarez (Liverpool), Alfaro (Liverpool de Montevideo), Fernandez (Malaga)