Rutten's side are level on 21 points with Twente in the standings, but the coach is hoping they can pull away to match pace setters AZ at the top of the table.
"We won’t make the trip to Enschede just to get a share of the points; we are keen to take all three," Rutten told the club's official website.
"PSV boast a rich history, while Twente are writing history. That’s why I expect an open game. Being aware and alert can make the difference."
The coach said Twente are still a solid side, despite selling key players in the summer transfer window.
"They are an extraordinary team. They let [Bryan] Ruiz and [Theo] Janssen leave the club during the summer transfer window but have filled the gap left by the two stars with the signing of some solid players," added Rutten.
"They are physically strong and enjoy a good home record.
"But we’ve put in fine displays on our travels in Europe and I feel confident ahead of tomorrow night’s clash."
Kick-off at De Grolsch Veste is at 20.45CET.
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