The Azzurri boss has vowed that his men want to bag the full three points in order to qualify, while Andrea Pirlo is optimistic about their chances of going through
The Euro 2012 finalists will book their ticket for the round of 16 if they avoid defeat against the Uruguayans, but Prandelli has made it clear that Italy are determined to bag the full three points and qualify in style.
"I have told the lads to believe in themselves and that they will qualify. We are determined to win this game. In order to get a good result, we will have to approach the game with the intention to win it," Prandelli said at the pre-match press conference.
"We are not the kind of team to go out there and play for a draw. I don't want to see the team suffer on the pitch. We have to show courage and fight for a good result. A very difficult task awaits, because it will be all or nothing.
"After the draw, I already said that it would all come to the final group game. This cannot be compared to anything. It's the biggest game of my career as a coach."
Experienced midfielder Andrea Pirlo, meanwhile, has backed up his coach's opinion that Italy should go out to play for the win as they target qualification for the knockout stages.
"We are not worried. We are all aware that an important game awaits. We know our strengths and what we have to do to emerge victorious.
"We hope to be able to play our own game. You will see a different Italy than against England and Costa Rica. We will not be playing for a draw."
Italy triumphed over England 2-1 in their opening game, before they were beaten 1-0 by Costa Rica on matchday two.