The Three Lions looked bright up front even in defeat in Manaus, with Raheem Sterling particularly impressive, and the manager is keen to continue that positive philosophy.
He confirmed to BBC Sport that England would again attack on Thursday, explaining: "We've been working towards this philosophy and now we have the players that can help us carry [it] out.
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"It's a defeat and you can't come away from the fact that defeats are never positive, but we've done our soul-searching now. We've analysed and put that game in perspective. I believe that we're ready now to move on, go to the next one and approach it in exactly the same way as we approached the Italy game."
Goal understands that Wayne Rooney is set to be used in a more central role after cutting a frustrated figure on the flanks against the Azzurri, though Hodgson says that the team have not yet been told how they will line up.
"We'll see," he added of the forward's role. "At the moment I'm not prepared to make any comments about the team. The players have always got to be the first to know and I can honestly tell you the players do not know what the team is. Rooney does not know if he's playing [or the] position in which he’d be playing.
"We're very flexible. We have a group of players behind either Sturridge, Welbeck or Rooney as centre-forward who can move about in the game and they're all comfortable wherever they play because they know the job there."
Asked if he is tired of talking about Rooney, Hodgson replied: "No, not really. I've got great admiration for him.
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After Uruguay were stunned by Costa Rica in a 3-1 loss in their first game, the England boss expects them to be better in Sao Paulo, though he feels that the match will be no harder for it than when his side faced Italy.
"It [wasn't] the type of Uruguay performance that we are used to or that we are preparing for – and they'll have their talisman back for this game. Luis Suarez, I'm sure, will play and we all know from the Premier League what a handful he is and how many qualities he brings to the game," Hodgson remarked.
"We'll have our work cut out but I don't necessarily think we'll face a tougher task [than Italy]. It could be equally as tough but there was the handicap that the game against Italy was played in Manaus. The temperature and conditions in Sao Paulo will be a bit kinder to us."