The coach is confident his team can keep the Ballon d'Or winner quiet in their opening World Cup match on June 16
Die Mannschaft take on Paulo Bento's men on June 16 before fixtures against Ghana and USA in a tough-looking Group G.
"Portugal are a great team and Cristiano's a fantastic player, but we've got the players and methods to stop him," the 54-year-old told reporters.
Low also explained his side's decision to play Armenia in their final warm-up match before the World Cup, as well as giving some team news ahead of the fixture.
"We deliberately chose to play Armenia as they play a similar counter-attacking style to Portugal," he added.
"Roman Weidenfeller will be playing. Manuel Neuer will not play ... but he will be fit to face Portugal in Brazil."
"[Philipp] Lahm and [Bastian] Schweinsteiger will be given some playing time. Both have trained individually over the last few days."