The Chelsea defender is brimming with confidence ahead of the World Cup and has urged his side to defend as a team against the Barcelona forward
Stephen Keshi's men take on the South American favourites in their final Group F game and Omeruo is eagerly anticipating the chance to lock horns with the Barcelona star.
"I’m really looking forward to the game against Argentina," the defender told fifa.com.
"I watch Messi a lot on TV. It’s going to be a team effort to try and stop him. Everyone will have to be positive and 100 per cent focused on the game.
"We will try as much as possible to keep a clean sheet. It will be difficult but we have to do that. They are the best players in the world and we have to show our quality by standing up to them."
Omeruo then went on to voice his side's ambition to reach at least the semi-finals in Brazil.
"We will first of all have to make sure we get maximum points from the first two games.
"I’m hoping we’ll get to the final, but I think at least the semi-finals."
Aside from Argentina, Nigeria also meet Iran and Bosnia-Herzegovina at this summer's showpiece.