The attacking midfielder started alongside Pedro and Cesc Fabregas furthest forward for La Furia Roja, but minutes after teammate Sergio Busquets was clattered by Patrice Evra, Silva looked to be struggling.
After a few moments of attempting to run off the knock, Silva was forced to leave the pitch, clutching his right knee and his hamstring before heading straight for the tunnel at the Vicente Calderon in Madrid, with Arsenal's Santi Cazorla replacing him.
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|30/1||Bet365 are offering odds of 30/1 that Carlos Tevez will open the scoring in a 2-1 win for Man City|
Following hard on the heels of West Brom is a trip to Amsterdam on Wednesday where they will face Ajax in the Champions League, and after a disappointing draw at home to Borussia Dortmund in matchday 1, City will be desperate to get their first win.